Cannabidiol (CBD), a non-psychoactive segment of the marijuana plant, has created huge enthusiasm among researchers and physicians. CBD Oil applies its remedial effect on an atomic level is as yet being sorted out. Cannabidiol is a pleiotropic sedate in that it produces numerous impacts through various atomic pathways. CBD Oil acts through different receptor-free channels and by official with various non-cannabinoid receptors and particle channels.

The tincture is available in three strengths: 500mg, 1,000mg, and 3,000mg. Prices range from $0.04 to $0.07 per mg, depending on the concentration, which makes the tincture very low-priced compared to oils from most competing brands. Medterra also offers a 30-day satisfaction guarantee and will issue full refunds for all returns. In addition to the tincture, Medterra also offers CBD capsules in 25mg and 50mg concentrations.
CBD has proven neuroprotective effects and its anti-cancer properties are being investigated at several academic research centers in the United States and elsewhere. A 2010 brain cancer study by California scientists found that CBD “enhances the inhibitory effects of THC on human glioblastoma cell proliferation and survival.” This means that CBD makes THC even more potent as an anticancer substance. Also in 2010, German researchers reported that CBD stimulates neurogenesis, the growth of new brain cells, in adult mammals.
At the top of our ranking is Utah-based Kanibi, which is on a mission to create high-quality, science-based CBD products with total transparency. Their consciously crafted CBD is sourced from organic, Kentucky-grown hemp which is farmed with organic farming methods. With great tasting products, free shipping, and a 30-day, no questions asked return policy, you really can’t go wrong with Kanibi.

We suggest using our dosage calculator to find the right dose or amount of CBD for your needs. If you are looking for relief for a specific issue, for example, back pain we suggest starting with our CBD Quiz to find the right product for you needs. Also if a organic or Non-GMO product is important for you look for that on the label or in the product description. Lastly, understand if you would prefer a full-spectrum cbd oil or a CBD isolate.  A full-spectrum oil contains many other beneficial parts of the hemp/cannabis plant while an isolate removes everything except CBD. Learn more about the difference here here.
Quality CBD oil comes from a quality source. CBD oil can be extracted from the hemp plant in a variety of ways. The safest, and most efficient methods, use carbon dioxide or ethanol as a solvent to separate the CBD from the hemp plant. All of the tinctures below are extracted from pesticide-free hemp grown on local farms in the United States, all of which are registered with their state’s industrial hemp pilot program, or organic-certified farms in Europe.
It’s important to know that there is no “best” brand or product for everyone. The best CBD oil is the one that works well for you. Each person has a unique endocannabinoid system, body chemistry, and severity of the condition. A brand or product that works well for one person with a specific situation may not work for you at all. This reality is understandably frustrating for many of those who are new to CBD oil. 

Generally, your dose depends on two key factors: your body weight and the severity of your symptoms. The more you weigh, and the more severe your symptoms, the more CBD you’ll likely need to take to feel relief. Although, every person has a unique body chemistry and personal receptivity to CBD, so don’t be worried if you find a lower or higher dose to be more effective for you than what’s “typical.” What’s important if that you find a dose that works!

*[A couple things of note before I begin the reviews. In order to avoid redundancy and limit repeating myself dozens of times over, be advised that (unless otherwise noted), all of the companies listed below employ standard practices that are used by all of the best CBD oil companies, including things like: solventless CO2 extraction, 3rd party laboratory testing, legal THC limits below 0.3%, shipping to all 50 U.S. states, etc..]


What exactly is cannabidiol (CBD) and more importantly, what does it do? Those questions and more are at the heart of this comprehensive guide to one of the most fascinating and important compounds of the cannabis plant. Cannabis plants are chemical powerhouses that produce more than 400 different compounds. Not all of those compounds are unique to marijuana, of course, and appear in many other species of plants. That’s why marijuana can smell like pine trees or taste like fresh lemons. But of those 400 compounds, more than 60 of them are totally specific to the plant genus Cannabis. Scientists call these special compounds “cannabinoids.” However, not all cannabinoids are created equal. One of them, cannabidiol, or CBD, holds the key to the wide variety of medicinal and therapeutic effects marijuana offers.
When I went into the CBD American Shaman store, the manager seemed extremely knowledgeable, was certified, spent quite a bit of time explaining the different aspects of their products. I bought the full spectrum VG Cloud Tincture in strawberry banana and the 250 Topical Cream, which he said I would be amazed how well it worked. Hmmm. Maybe not so much, at least not yet. And the oil hasn’t helped as much as I hoped. Because they have a “Compassionate Care” program for those with disabilities, I was hoping this would be the one. Most of our family suffers from chronic pain and has had to go on disability, much to their chagrin. The products are $59.95 each, and the discount would be something like 30 per cent.
The human body also produces cannabinoids, known as endocannabinoids, in a bodily system known as the endocannabinoid system (or ECS). The ECS promotes homeostasis by regulating a wide range of functions, including motor skills, mood, appetite, and sleep. As we age, our ECS produces fewer endocannabinoids; they may also decrease due to physical injury or disease. Replenishing depleted endocannabinoids with phytocannabinoids like CBD can help restore balance to the body.
“Buying from a reputable manufacturer is crucial, because it matters how the plant is cultivated and processed,” Dr. Maroon says. One clue that a company is cutting corners: too low a cost. Good CBD is pricey—a bottle of high-quality capsules is sold in Cohen’s office for $140. But for many, it’s worth the money. Roth spent $60 on her tiny bottle. But when her energy returned the day she started taking CBD, she decided that was a small price to pay.
Vape Pens – Perhaps the easiest way to get the CBD Oil into your body is through a vape pen. A vape pen is about the size of an ink pen but has a CBD oil cartridge with a heating element. Many people like vape pens because there is very little in the way of odor after using it and it allows for a lot of discretion because it can be pulled out of your pocket and used on demand. CLICK HERE to see our favorite vape pens.
In your internet travels, you may also come across products called “terpsolates.” The manufacturers of these products infuse CBD Isolate with terpenes (but not cannabinoids like THC). These terpenes may enhance the effectiveness of CBD — or maybe they just make it smell good. This may be a good place to point out that not all CBD products are created equal. The industry is still largely unregulated, and the quality and quantity of CBD in a given product will vary wildly. Third-party testing definitely helps to monitor companies’ claims, but it’s still up to you as the consumer to do your homework on the best CBD products.
Spruce was founded by Tony Spencer, who had a clear mission for his company—give people access to safe and effective lab-grade, hemp-based CBD. Spencer realized that many other CBD oils on the market were low-potency and simply didn’t work. “We have a lot of customers in pain who have wasted money on CBD products in the past that didn’t work for them,” remarks Spruce on their website.
If you haven’t been bombarded with CBD marketing or raves about it from friends, get ready. This extract—which comes from either marijuana or its industrial cousin, hemp—is popping up everywhere. There are CBD capsules, tinctures, and liquids for vaping plus CBD-infused lotions, beauty products, snacks, coffee, and even vaginal suppositories. Already some 1,000 brands of CBD products are available in stores—and online in states that don’t have lenient cannabis laws. This is a tiny fraction of what’s to come: The CBD market is poised to exceed $22 billion by 2022, per the Chicago-based research firm Brightfield Group.
Another field in which CBD is creating a buzz is in the area of mood disorders like anxiety and depression. Both conditions have been treated with a variety of medications, courtesy of Big Pharma, that have had varying levels of success. Again, the long list of side effects can be off-putting to someone who just wants to get through the day without the sweaty tension of anxiety or the gray haze of depression.
Given CBD’s reputation as a popular, artisanal remedy, one would think that Epidiolex would command a lot of “off label” attention. After all, physicians often prescribe pharmaceuticals off label to treat conditions that were not the actual focus of clinical trials. But the costly price tag for Epidiolex (more than $30,000 annually) precludes off label prescribing as well as affordable access for tens of millions of Americans without health insurance.
Drops (also referred to as tinctures) are the most popular way to take CBD oil. They are typically sold in glass bottles with a built-in dropper. The drops are placed under your tongue and held there for at least 60 seconds. This drop process allows the CBD to absorb sublingually into your bloodstream. Other popular ways to take CBD include vaping, gummies, capsules, and topical creams. How you take it is a personal decision based on your preferences. Many experienced users take multiple different products at the same time.
What you gain from Full Spectrum CBD is called the “entourage effect.” Studies have suggested that CBD is most effective when it’s combined with other cannabinoids. Each cannabinoid has its own properties and confers its own benefits. Working together, a synergy is created that boosts the healing properties of CBD. Full spectrum CBD does, however, bring with it the sticky issue of THC. The government regulates concentration levels of THC at 0.3 percent, an amount which results in minimal psychoactivity.
This is why Amanda Oliver, 31, a career consultant in Charleston, SC, pops a CBD gummy bear each night before bed. “I used to lie there tossing and turning as my mind raced from work projects to whether I had set the home alarm,” Oliver says. One piece of candy with 15 milligrams (mg) of CBD is enough to shut off her brain and facilitate sleep. She also swears by the CBD oil she takes at the height of her period, which she says quells her debilitating cramps.
According to Ananda Hemp’s website, it’s something of a trailblazer in the CBD world, for it possesses what it maintains to be the U.S.’ first officially authorized hemp farm. Ananda Hemp also claims to be the earliest business to have legally imported its own hemp seeds – taken from what is said to be the most extensive privately owned cannabis seed bank in the world. This, the company says, “stands in contrast to many of [its] competitors, who are sourcing questionable, non-certified and untraceable CBD sources.” In any case, people who wish to see how Ananda Hemp’s process impacts on its products can see for themselves by using its full-spectrum extracts, softgels and topical salve. Those goods have themselves, it seems, been through the testing process a minimum of three times to ensure that their levels of potency live up to what’s written on the labels.
Brian Peterson has been a CBD consumer advocate and educator since 2013. He is the founder and managing editor of the CBDOilUsers.com website. He's also the lead administrator of the CBD Oil Users Group, the largest CBD group on Facebook. His passion is educating consumers so that they can make their own decisions when purchasing and using CBD products.
Don’t let the name confuse you. CBD oil comes in many shapes and forms besides the traditional oils that we’ve highlighted here. CBD tinctures are the most popular type of CBD oil, because they tend to have more potent concentrations and offer high bioavailability (e.g. more CBD gets absorbed through your bloodstream when you apply it beneath your tongue as a tincture). Plus, users typically begin to feel the effects within minutes.
If you are discovering the benefits of CBD then our Pure CBD e-liquids may be the best place to start. Vaping is the recommended and one of the most effective method of consuming CBD as vaping facilitates absorption into the body. Our CBD vape liquid is produced for VSAVI in Europe in “Clean Room” laboratories. It is safe, natural, pure and free from both contaminates and THC.

Transparency: Fab’s website features third-party lab results for most products. They only have a lab test for one of their tinctures though (which shows results for cannabinoid potency, as well as contaminants like pesticides). Customer service pointed out that the same CBD oil is used for all their products, but since potencies do vary, we appreciate companies that show potency testing for all products.

Currently, the only CBD product approved by the Food and Drug Administration is a prescription oil called Epidiolex. It's approved to treat two types of epilepsy. Aside from Epidiolex, state laws on the use of CBD vary. While CBD is being studied as a treatment for a wide range of conditions, including Parkinson's disease, schizophrenia, diabetes, multiple sclerosis and anxiety, research supporting the drug's benefits is still limited.
Transparency: Fab’s website features third-party lab results for most products. They only have a lab test for one of their tinctures though (which shows results for cannabinoid potency, as well as contaminants like pesticides). Customer service pointed out that the same CBD oil is used for all their products, but since potencies do vary, we appreciate companies that show potency testing for all products.
The CBD oil in everything that’s sold by Receptra Naturals is extracted from hemp from family-owned farms in Colorado. And the oil produced by the hemp plants – which are cultivated completely organically – is only taken from the flowering parts to ensure its purity and quality. Those of an environmentally conscious bent may therefore particularly appreciate the company’s offerings, which include CBD oil blends that aim either to boost users’ overall sense of health or, for people who are particularly physically active, to just give them a bit more pep in their steps. The most potent of these oils is, for the record, a 4,000 mg concentrate. But Receptra Naturals’ range also includes a topical cream, a skin-conditioning body butter and a CBD extract blend for pets that, the producer states, may help with anxiety, mobility and digestion in animals.
Buying CBD has never been easier. Since CBD from the Hemp plant does not contain unlawful measures of THC, it is legitimate in every one of the 50 states. This is imperative to individuals everywhere throughout the US who need CBD however can’t get it locally. What’s more, legitimate CBD is accessible for home conveyance in every one of the 50 states meaning numerous individuals don’t need to move to a state with sanctioned Medical Marijuana. Additionally, in states where medicinal weed is lawful, buyers utilizing this hemp plant type of CBD don’t need to obtain a medical marijuana card.
Along with PureKana and CW Hemp, I would say that Green Roads CBD oil probably rounds out the top 3 most popular hemp companies selling online, and that would generally translate to status as the “best CBD oil,” right? They have an incredible web presence, and in fact run a really great blog that you should keep up with if you’re interested in the latest CBD news, trends, etc. They’re also big into offering loads of different product, including pre-dosed pens called “Daily Doses,” CBD terpenes, edibles, and even potent CBD concentrates that you can dab (I don’t have a dab rig myself, but I have friends who say the potency is incredible). Honestly, you’ve just got to check out their website in order to get a better idea of the huge range of products they’ve got — all of which are of the highest quality.  

Dry Mouth: As is the case with many other hemp- and marijuana-based products, CBD oil often leads to a condition known as dry mouth (or cottonmouth). This is likely due to cannabinoids altering receptors in the lower jaw that trigger salivation. In most cases, mild discomfort and stronger-than-average thirst are the only issues associated with dry mouth.

×