Most human studies of CBD have been done on people who have seizures, and the FDA recently approved the first CBD-based drug, Epidiolex, for rare forms of epilepsy. Clinical trials for other conditions are promising, but tiny. In one Brazilian study published in 2011 of people with generalized social anxiety disorder, for example, taking a 600-mg dose of CBD (higher than a typical dose from a tincture) lessened discomfort more than a placebo, but only a dozen people were given the pill.
Most products labeled “hemp oil” do not contain any CBD. Those are typically hemp seed oil which is more commonly used for cooking or to make salad dressing. If you want to buy CBD oil, you’ll want to look for products that are labeled “CBD oil” or “hemp extract.” To confirm that a product you’re interested in has CBD in it, you’ll want to look at their third-party lab reports. All reputable companies selling CBD oil products will make third-party lab reports available to you to confirm the presence of CBD.
There are two possible exceptions to this. The first is that some people, for unknown reasons, just react differently to CBD. According to Dr. Chin, about 5% of people say they feel altered after taking CBD. "Usually they're the same people who have side effects from Advil or Tylenol," she says. You never know how your body will react to any new supplement, so when taking CBD for the first time, do so safely under supervision.
Additionally, PlusCBD oil is incredibly rigorous and transparent when it comes to testing their products and sharing the results. They perform thorough in-house testing to verify potency and screen for contaminants. PlusCBD Oil also validates its own in-house testing with independent third-party testing via DB Labs to ensure all products are free of pesticides, fungicides, residual solvents, heavy metals, and microbiological contamination.
These policies vary widely. Marijuana and CBD are currently fully legal for both medicinal and recreational purposes in Alaska, California, Colorado, Maine, Massachusetts, Michigan, Nevada, Oregon, Vermont, Washington, and Washington D.C. In 23 states, it's legal in some form, such as for medicinal purposes. Another 14 states permit just CBD oil. But both are illegal in Idaho, Nebraska, and South Dakota. For more information, the organization Americans for Safe Access has a helpful guide to the specific laws in each state.
Historically, hemp could legally be grown and cultivated for academic research purposes only. However, the legality of hemp growth has changed in the past year. In April 2018, Sen. Mitch McConnell of Kentucky introduced the Hemp Farming Act of 2018, a piece of legislation that proposed legalizing all hemp products at the federal level. The act was incorporated in the 2018 United States Farm Bill, which passed in both the House and Senate in December 2018. Per the farm bill, industrial hemp will be descheduled as a federally controlled substance.
Fab CBD offers full refunds for all products returned within 30 days of the original purchase. Inexpensive shipping rates are also available; most customers receive their delivery within seven or fewer business days. Customers can contact Fab CBD by phone or email if they have questions or concerns about their delivery. Those who join the brand’s online community qualify for product discounts, as well.
Don’t let the name confuse you. CBD oil comes in many shapes and forms besides the traditional oils that we’ve highlighted here. CBD tinctures are the most popular type of CBD oil, because they tend to have more potent concentrations and offer high bioavailability (e.g. more CBD gets absorbed through your bloodstream when you apply it beneath your tongue as a tincture). Plus, users typically begin to feel the effects within minutes.
People taking other medications: When side effects are reported, it’s often by this group. CBD appears to have a similar effect to grapefruit on the liver’s ability to metabolize certain drugs, which can lead to adverse side effects. Generally, if a medication has a grapefruit warning, you should avoid taking CBD. Although, if you are on any medication you should talk to your doctor before starting CBD, to ensure you won’t expect any negative interactions.
Cutting-edge science has shown that the endocannabinoid system is dysregulated in nearly all pathological conditions. Thus, it stands to reason that “modulating endocannabinoid system activity may have therapeutic potential in almost all diseases affecting humans,” as Pal Pacher and George Kunos, scientists with the U.S. National Institutes of Health (NIH), suggested in a 2014 publication.

San Francisco’s Johnny Apple CBD assures customers that it only uses organic, non-GMO hemp plants for its CBD extract. In addition, the company declares, it’s put the time and effort into ensuring the genetic quality of the raw material. Perhaps that rigorous process has helped Johnny Apple CBD in securing the often-superlative reviews given to its products, which have in total earned the company an “excellent” TrustSpot rating. Those duly tempted to purchase from the producer can take their pick from CBD oil blends specially formulated to encourage either tranquility, happiness or clear-headedness. Also available are a wax designed for dabbers, a cocoa butter “calm balm” and 99 percent-pure CBD in crystals – the finer variety of which, Johnny Apple CBD explains, is entirely suitable for adding to baked goods.
Whether you are looking for CBD for general wellness or for specific medical conditions it’s important to look for these forms of lab test results; heavy metal testing, clinical trial information (if available), pesticide testing, microbial testing, potency testing, and cannabinoid profile. While having this information provided by a CBD company is important, it doesn’t necessarily mean their product will work for you. However you do not want to consider a CBD company that doesn’t provide the testing info mentioned above. Learn more about recommended best practices to look for here.
CBD oil fans who switch between vaping and sublingual use are ably catered for by CBD Drip. That’s because the company sells an innovative range of full-spectrum oils that can not only be mixed with regular e-liquids or vaped by themselves but which may also be added to food and drink or simply applied under the tongue. For individuals who’d rather make up their own CBD oil-infused products, meanwhile, the company even offers concentrate in bulk. And CBD Drip assures its customers as to the purity and efficacy of its merchandise by explaining in detail on the website what is tested for and why; full lab results for many of its goods are also available to view at a click.

CBD products have seen a huge rise in popularity over the past four years, beginning when the Agricultural Act of 2014 allowed the growth of industrial hemp. CBD oil has gained serious traction in the alternative medicine market, where it is reported to help with sleep disorders, migraines, pain relief (especially neck pain), anxiety, and even epilepsy. Because it contains 0–.3% THC (the psychoactive cannabinoid in marijuana), CBD appeals to a wide range of people, including those who would not have used medical marijuana due to the head high they would experience.
Los Angeles-based PureKana stresses that it extracts the CBD oil for its products from hemp plants that have been cultivated without the use of herbicides, pesticides or other agro-industrial chemicals that may impact upon crops. What’s more, the company states, no solvents go into the extraction process other than carbon dioxide. And to further put potential customers’ minds at rest, PureKana presents the results of third-party testing of its CBD oil tincture on its website – a welcome nod to transparency. That tincture can be found in the company’s own blend of CBD oil drops – the three varieties of which have elicited highly complimentary reviews from users – as well as its capsules and cooling topical ointment. Meanwhile, for anyone with a sweet tooth, PureKana’s CBD isolate-containing gummy bears may just do the trick.
NuLeaf Naturals CBD oil tinctures are all full spectrum; it is 100% organic and never made with herbicides, pesticides, or chemical fertilizers. The brand offers a full spectrum pet CBD oil tincture, as well. NuLeaf Naturals offers free shipping to all 50 states; the brand’s products are also sold in more than 1,000 retail locations across the country.

Like Premium Jane, Fab CBD is another newcomer to the industry, and they made this list simply because of how affordable they are. We received some samples quite awhile back, and while they weren’t the most potent products in the world, they absolutely did work and if you were to buy them from the online store they are about 15% cheaper than other top brands. ($79 for a 600 mg bottle compared to the average $95).
SabaiDee entered the CBD industry looking to make a difference. The company’s founders wanted to help people live happier and more productive lives by sharing the benefits of CBD. But they were shocked by many of the bad practices rampant in the CBD industry—misleading labels, questionable manufacturing processes meant to maximize profits, and a lack of transparency about sourcing and quality testing.
Cannabis grabbed all the headlines when Colorado legalized it on November 6, 2012 by passing Amendment 64. What most people don’t know is that hemp (the cultivar of cannabis with less than .3% THC) was allowed to be cultivated (originally in Kentucky and later in Colorado and Tennessee) under the 2014 farm bill. Hemp was grown initially as a pilot project, but as of today the US Congress is close to removing the Schedule 1 status of hemp. Removing the draconian Schedule 1 status as a controlled substance would allow hemp to grown in all of The United States. 
Quality CBD oil comes from a quality source. CBD oil can be extracted from the hemp plant in a variety of ways. The safest, and most efficient methods, use carbon dioxide or ethanol as a solvent to separate the CBD from the hemp plant. All of the tinctures below are extracted from pesticide-free hemp grown on local farms in the United States, all of which are registered with their state’s industrial hemp pilot program, or organic-certified farms in Europe.
Terpenes are the naturally-occurring essential oils from plants, flowers, and vegetables. Terpenes are what give the plant its scent, flavor, and unique benefits. Some of the terpenes in cannabis are known for their useful therapeutic properties. For example, some terpenes are known for their anti-inflammatory, anti-anxiety, or relaxing properties to name a few.

CBD (Cannabidiol) is a potent, non-psychoactive cannabinoid found in hemp oil. It is typically extracted from industrial hemp plants that are naturally high in CBD and other phytochemicals. It is the most prevalent of over 80 different cannabinoids found in natural hemp. It is commonly used for its therapeutic properties. Cannabidiol is responsible for a wide-range of positive health benefits through its interaction with the body's own endocannabinoid system.


Cannabidiol, or CBD for short, is a phyto-cannabinoid found in cannabis plants. However, it does not cause the same psychoactive effects as other naturally occurring cannabinoids (such as tetrahydrocannabinol, or THC). CBD induces feelings of sleepiness and tranquility, making it suitable for insomnia and other sleep disorders; CBD can be used to alleviate symptoms of epilepsy, diabetes, and anxiety disorders, as well. Legality is an issue for some; all 50 states have laws governing the sale, possession, and use of CBD, and they vary significantly (see the table below for a full analysis).
Tinctures – Typically tinctures are small glass or plastic “dropper” bottles that have cannabidiol oil mixed with a preserving solution such as alcohol. Tinctures were very a very common way to ingest botanical oils prior to the industrial revolution and are experiencing a resurgence in popularity as more people are looking for natural remedies. Tinctures with droppers allow you to put a few drops in your tea, under your tongue, or to bake the oil directly into your food. CLICK HERE to see our favorite tincture.
Not all CBD is created equally. Some tinctures are created with little regard to overall consumer safety, and may contain harmful chemicals and pesticides. Other CBD products have been shown to differ from what the label says, either with way more cannabidiol, or way less. In some cases, the THC content was elevated above the federal legal limit for hemp extracts.
If you haven’t been bombarded with CBD marketing or raves about it from friends, get ready. This extract—which comes from either marijuana or its industrial cousin, hemp—is popping up everywhere. There are CBD capsules, tinctures, and liquids for vaping plus CBD-infused lotions, beauty products, snacks, coffee, and even vaginal suppositories. Already some 1,000 brands of CBD products are available in stores—and online in states that don’t have lenient cannabis laws. This is a tiny fraction of what’s to come: The CBD market is poised to exceed $22 billion by 2022, per the Chicago-based research firm Brightfield Group.
Terpenes are the naturally-occurring essential oils from plants, flowers, and vegetables. Terpenes are what give the plant its scent, flavor, and unique benefits. Some of the terpenes in cannabis are known for their useful therapeutic properties. For example, some terpenes are known for their anti-inflammatory, anti-anxiety, or relaxing properties to name a few.
Quality CBD oil comes from a quality source. CBD oil can be extracted from the hemp plant in a variety of ways. The safest, and most efficient methods, use carbon dioxide or ethanol as a solvent to separate the CBD from the hemp plant. All of the tinctures below are extracted from pesticide-free hemp grown on local farms in the United States, all of which are registered with their state’s industrial hemp pilot program, or organic-certified farms in Europe.
And now, onto the thorny issue of legality. The simple answer to the question is yes — if it is extracted from hemp. The 2014 Farm Bill established guidelines for growing hemp in the U.S. legally. This so-called “industrial hemp” refers to both hemp and hemp products which come from cannabis plants with less than 0.3 percent THC and are grown by a state-licensed farmer.
Since 2014, NuLeaf Naturals – our Editor’s Pick – has been committed to creating high-quality CBD oil products. As one of the oldest and most reviewed companies in the industry, NuLeaf Naturals has established themselves as a trustworthy CBD manufacturer. All of their products are tested by third party labs and their cannabinoid profile is impressive. They offer a unique range of concentrations for their organic CBD products ranging from 240mg to 4,850mg.
CBD derived from marijuana is a different story, and the law varies from state to state. But as long as you’re using CBD oil that contains less than 0.3 percent THC, you have nothing to be concerned about anywhere in the United States. On the other hand, if you want to take your CBD on a trip outside the country, definitely look into local laws to avoid getting into awkward situations while you’re away.
Fab CBD offers an extensive line of deliciously flavored full-spectrum CBD oils in a broad range of potencies. You can choose between citrus, vanilla, mint, berry, and natural flavors and potencies of 5 mg, 10 mg, 20 mg, 40 mg, or 80 mg of CBD per serving. And like all of our favorite CBD brands, Fab CBD uses minimal ingredients with no additives—just hemp extract, coconut oil, and natural flavors.

CBD oil products generally have a shelf life of at least one year, if stored in a cool, dark place. Refrigeration is typically not necessary as long as it is kept somewhere where the temperature is less than 77 degrees Fahrenheit. Tinctures that use MCT coconut oil as the carrier oil are known to have a longer shelf life than those with hemp seed oil as the carrier oil.
Brian Peterson has been a CBD consumer advocate and educator since 2013. He is the founder and managing editor of the CBDOilUsers.com website. He's also the lead administrator of the CBD Oil Users Group, the largest CBD group on Facebook. His passion is educating consumers so that they can make their own decisions when purchasing and using CBD products.
CBD oil fans who switch between vaping and sublingual use are ably catered for by CBD Drip. That’s because the company sells an innovative range of full-spectrum oils that can not only be mixed with regular e-liquids or vaped by themselves but which may also be added to food and drink or simply applied under the tongue. For individuals who’d rather make up their own CBD oil-infused products, meanwhile, the company even offers concentrate in bulk. And CBD Drip assures its customers as to the purity and efficacy of its merchandise by explaining in detail on the website what is tested for and why; full lab results for many of its goods are also available to view at a click.

*[A couple things of note before I begin the reviews. In order to avoid redundancy and limit repeating myself dozens of times over, be advised that (unless otherwise noted), all of the companies listed below employ standard practices that are used by all of the best CBD oil companies, including things like: solventless CO2 extraction, 3rd party laboratory testing, legal THC limits below 0.3%, shipping to all 50 U.S. states, etc..]

In 2016 Louisville, Colorado-based Bluebird Botanicals was selected as the leading CBD oil company in the U.S. at that year’s Cannabist Awards, and that accolade came only four years after the business’ founding. In that time, though, Bluebird Botanicals has, according to cannabis industry market researchers Brightfield Group, grown to become the third-biggest selling producer of its kind in America. Perhaps that’s down in part to the stringent quality control measures that Bluebird Botanicals maintains – the results of which can be seen when looking at the certificates of analysis for each batch on its website. And the company’s “assistance programs,” created to aid disabled people, veterans and those on low incomes, also speak to an altruistic approach to customer care. People eligible can receive discounts on Bluebird’s classic and signature hemp extracts, vape oil and CBD isolate.
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