Several weeks after a hysterectomy last spring, Bo Roth was suffering from exhaustion and pain that kept her on the couch much of the day. The 58-year-old Seattle speech coach didn’t want to take opioid pain-killers, but Tylenol wasn’t helping enough. Roth was intrigued when women in her online chat group enthused about a cannabis-derived oil called cannabidiol (CBD) that they said relieved pain without making them high. So Roth, who hadn’t smoked weed since college but lived in a state where cannabis was legal, walked into a dispensary and bought a CBD tincture.

Cost is another consideration. Most CBD oils are sold in concentrations of 300 to 750 mg, although this may range from less than 100 mg to more than 2,000. A good indicator of price-point is the cost per milligram. Low-cost CBD oils usually fall between five and 10 cents per mg; mid-range prices are 11 to 15 cents per mg; and higher-end oils cost 16 cents per mg or higher. Given these varying per-milligram costs, a bottle of CBD oil may be priced anywhere from $10 or less to $150 or more.


Fab has rapidly become the leading “lifestyle” brand in the industry. They are very engaged with their customers in their online community, and they have the top customer loyalty program that we’ve seen. Their full spectrum CBD oil drops and topical cream are made from 100% organically grown Colorado hemp, producing a very high-quality product. And their zero THC gummies get high marks from customers for taste and effectiveness.
The CBDistillery has two main strengths. The first is its variety of options. The CBDistillery offers CBD oil tinctures in a wide range of concentrations from 17mg up to 88 mg of CBD per serving. But what really sets the company apart is that they offer both full-spectrum and THC-free CBD oil options. Most people gravitate towards full-spectrum CBD oil to take advantage of the entourage effect. But with THC-free CBD oil, you can enjoy the benefits and effects of CBD even if you’re subject to mandatory drug testing.
Several weeks after a hysterectomy last spring, Bo Roth was suffering from exhaustion and pain that kept her on the couch much of the day. The 58-year-old Seattle speech coach didn’t want to take opioid pain-killers, but Tylenol wasn’t helping enough. Roth was intrigued when women in her online chat group enthused about a cannabis-derived oil called cannabidiol (CBD) that they said relieved pain without making them high. So Roth, who hadn’t smoked weed since college but lived in a state where cannabis was legal, walked into a dispensary and bought a CBD tincture.
CBD Essence is another brand we’ve had plenty of experience with over the past 18 months or so, and my partner particularly likes his 600 mg Medicinal Grade tincture for quickly easing her anxiety. I haven’t tried them so much for may pain, but I do recall that a 30 mg dose was quite effective the last time I did take it. Also, the main reason they’re this high up on our list is because they’re a fair amount cheaper than Elixinol and PureKana. Their tinctures come in larger 2 oz bottles, but on a CBD-per-mg basis they’re about 20% less expensive than other top-quality brands.
You’ve probably seen PureKana listed on several other “best CBD oils” lists, and it’s for good reason; in our experience (along with maybe a couple of other close competitors), they offer the best overall value in terms of potency, price, customer service, and most importantly, effectiveness. In fact, if I wasn’t continuously trying out new stuff and dedicated to reviewing every single hemp product on the market in an effort to reveal the absolute best CBD oil, I would probably use them exclusively for my lower back pain. Likewise, my partner has said several times that the 600 mg Vanilla tincture is one of his favorites for helping him sleep through the night.
There are two possible exceptions to this. The first is that some people, for unknown reasons, just react differently to CBD. According to Dr. Chin, about 5% of people say they feel altered after taking CBD. "Usually they're the same people who have side effects from Advil or Tylenol," she says. You never know how your body will react to any new supplement, so when taking CBD for the first time, do so safely under supervision.
CBDPure oils are made with non-GMO hemp, grown in Colorado by local farmers. Our hemp oil is minimally processed by following the highest organic standards at every step of our growing, harvesting, and bottling process. When you buy a CBDPure product, you are buying the purest CBD oil from natural sources, that is 100% free of any synthetic or artificial ingredients. We test every batch of oil that we process to ensure that it meets the purity standards that we demand.

If you live in a state where CBD is legal for your condition, it’s best to buy it from a state-regulated dispensary. But even there, oversight is uneven. “I feel safe being a cannabis consumer in Colorado, since the state tracks everything from seed to sale, but I didn’t the first few years after cannabis became legal,” when the rules were still taking shape, says Robyn Griggs Lawrence, the Boulder author of The Cannabis Kitchen Cookbook, which features recipes for cannabis edibles.


Real Scientific Hemp Oil touts itself as being somewhat of a pioneer, as – according to the company – its own variety of CBD oil was the first to hit the mainstream back in 2012. In addition, the brand claims that its RSHO-X CBD liquid is the earliest no-THC product of its kind, making it a sound choice for those worried about whether CBD oil use will influence the results of drug tests. The company is also transparent about the processes that go into making its varieties of CBD-containing hemp oils, helping customers make informed choices as to which of its products are best for them. And minds may be put at ease upon learning that Real Scientific Hemp Oil tests its CBD oil three times – a process which seems to speak to the quality, purity and safety of the provider’s wares.

The human body also produces cannabinoids, known as endocannabinoids, in a bodily system known as the endocannabinoid system (or ECS). The ECS promotes homeostasis by regulating a wide range of functions, including motor skills, mood, appetite, and sleep. As we age, our ECS produces fewer endocannabinoids; they may also decrease due to physical injury or disease. Replenishing depleted endocannabinoids with phytocannabinoids like CBD can help restore balance to the body.

Brian Peterson has been a CBD consumer advocate and educator since 2013. He is the founder and managing editor of the CBDOilUsers.com website. He's also the lead administrator of the CBD Oil Users Group, the largest CBD group on Facebook. His passion is educating consumers so that they can make their own decisions when purchasing and using CBD products.
The CBDistillery has two main strengths. The first is its variety of options. The CBDistillery offers CBD oil tinctures in a wide range of concentrations from 17mg up to 88 mg of CBD per serving. But what really sets the company apart is that they offer both full-spectrum and THC-free CBD oil options. Most people gravitate towards full-spectrum CBD oil to take advantage of the entourage effect. But with THC-free CBD oil, you can enjoy the benefits and effects of CBD even if you’re subject to mandatory drug testing.
Transparency seems to be a priority at Green Roads, as the company’s website explains in detail the process by which its CBD oil is created and what it contains. Potential customers might also be reassured to find out that Green Roads products have been carefully compounded by a pharmacist with more than two decades of experience in the field. Meanwhile, to help ensure the quality of its products, the company regularly subjects its CBD oil to third-party lab tests, the results of which can be found online. Such stringency may, in turn, account for the highly positive reviews afforded to Green Roads’ most potent CBD oil tincture – a 1,500 mg concentrate. And for those wishing to branch out beyond that, the producer offers a range of similarly acclaimed edibles, including gummie-men and lollypops, as well as CBD oil-infused night-time syrups, capsules, tea and coffee.
Extraction: The method by which CBD oil is processed from hemp plants can be very telling. Some manufacturers extract and process the oil using toxic materials like propane or butane; in most cases, these oils are cheaply priced. Safer extraction and processing agents include ethanol, which cleans the hemp plant of unwanted toxins; and supercritical carbon dioxide extraction, which strips harmful materials from the plant by changing the carbon dioxide’s temperature and pressure settings.
CBD Essence is another brand we’ve had plenty of experience with over the past 18 months or so, and my partner particularly likes his 600 mg Medicinal Grade tincture for quickly easing her anxiety. I haven’t tried them so much for may pain, but I do recall that a 30 mg dose was quite effective the last time I did take it. Also, the main reason they’re this high up on our list is because they’re a fair amount cheaper than Elixinol and PureKana. Their tinctures come in larger 2 oz bottles, but on a CBD-per-mg basis they’re about 20% less expensive than other top-quality brands.
Palmetto Harmony’s backstory is a poignant one, as founder Janel Ralph was spurred on to create the company to help her daughter Harmony, who suffers from an unusual genetic condition. However, according to the producer’s website, Harmony’s quality of life has greatly improved since she began taking CBD oil. And potential customers looking to see if their health could be changed for the better can select from Palmetto Harmony’s broad array of organic CBD oil-containing products, including the company’s flagship whole-plant extract and an unusual time-release patch. The brand’s Holy Cannacense cream, meanwhile, is among the most popular of its range; and also in demand is the acclaimed vape oil, which Palmetto Harmony claims “is best used to calm the mind and soothe inflammation.”
Employee-owned Lazarus Naturals touts its commitment to ethical business practices, including pricing that aims to enable anyone to sample its range. Indeed, for veterans and those with long-term disabilities, there’s even a commendable 40-percent discount on the company’s wares. Customers wanting more bang for their buck could, then, try Lazarus Naturals’ 3,000 mg flavorless CBD tincture, a 60 ml bottle of which costs $125, though an even more potent 6,000 mg tincture is also available. Plus, the supplier’s handy and inexpensive taster packs may be a boon for more indecisive or novice CBD oil users. These packs come in regular and high-potency varieties, both of which contain samples of the company’s tinctures, capsules and CBD-infused coconut oil.
But because all these products are illegal according to the federal government, cannabis advocates are cautious. “By and large, the federal government is looking the other way,” says Paul Armentano, deputy director of the Washington, DC–based National Organization for the Reform of Marijuana Laws (NORML), but until federal laws are changed, “this administration or a future one could crack down on people who produce, manufacture, or use CBD, and the law would be on its side.”
Palmetto Harmony’s backstory is a poignant one, as founder Janel Ralph was spurred on to create the company to help her daughter Harmony, who suffers from an unusual genetic condition. However, according to the producer’s website, Harmony’s quality of life has greatly improved since she began taking CBD oil. And potential customers looking to see if their health could be changed for the better can select from Palmetto Harmony’s broad array of organic CBD oil-containing products, including the company’s flagship whole-plant extract and an unusual time-release patch. The brand’s Holy Cannacense cream, meanwhile, is among the most popular of its range; and also in demand is the acclaimed vape oil, which Palmetto Harmony claims “is best used to calm the mind and soothe inflammation.”
If you live in a state where CBD is legal for your condition, it’s best to buy it from a state-regulated dispensary. But even there, oversight is uneven. “I feel safe being a cannabis consumer in Colorado, since the state tracks everything from seed to sale, but I didn’t the first few years after cannabis became legal,” when the rules were still taking shape, says Robyn Griggs Lawrence, the Boulder author of The Cannabis Kitchen Cookbook, which features recipes for cannabis edibles.
Online Retailers: Most CBD oils are sold through online retailers. These establishments tend to have the widest product range, and many offer free doorstep delivery. Online retailers also frequently post product reviews, allowing buyers to compare different oils based on customer experiences to determine which is best for them. These reviews can also be used to evaluate the retailer based on customer service, delivery, and product quality.
Palmetto Harmony’s backstory is a poignant one, as founder Janel Ralph was spurred on to create the company to help her daughter Harmony, who suffers from an unusual genetic condition. However, according to the producer’s website, Harmony’s quality of life has greatly improved since she began taking CBD oil. And potential customers looking to see if their health could be changed for the better can select from Palmetto Harmony’s broad array of organic CBD oil-containing products, including the company’s flagship whole-plant extract and an unusual time-release patch. The brand’s Holy Cannacense cream, meanwhile, is among the most popular of its range; and also in demand is the acclaimed vape oil, which Palmetto Harmony claims “is best used to calm the mind and soothe inflammation.”

Another field in which CBD is creating a buzz is in the area of mood disorders like anxiety and depression. Both conditions have been treated with a variety of medications, courtesy of Big Pharma, that have had varying levels of success. Again, the long list of side effects can be off-putting to someone who just wants to get through the day without the sweaty tension of anxiety or the gray haze of depression.
Sativex may interact with alcohol, affecting coordination, concentration, and ability to respond quickly. In general, alcoholic beverages should be avoided whilst using Sativex, especially at the beginning of treatment or when changing the dose. Patients should be advised that if they do drink alcohol while using Sativex the additive CNS effects may impair their ability to drive or use machines, and increase the risk of falls.
Cannabidiol (CBD) is a naturally occurring compound found in the resinous flower of cannabis, a plant with a rich history as a medicine going back thousands of years. Today the therapeutic properties of CBD are being tested and confirmed by scientists and doctors around the world. A safe, non-addictive substance, CBD is one of more than a hundred “phytocannabinoids,” which are unique to cannabis and endow the plant with its robust therapeutic profile.
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