Most human studies of CBD have been done on people who have seizures, and the FDA recently approved the first CBD-based drug, Epidiolex, for rare forms of epilepsy. Clinical trials for other conditions are promising, but tiny. In one Brazilian study published in 2011 of people with generalized social anxiety disorder, for example, taking a 600-mg dose of CBD (higher than a typical dose from a tincture) lessened discomfort more than a placebo, but only a dozen people were given the pill.


Not all CBD is created equally. Some tinctures are created with little regard to overall consumer safety, and may contain harmful chemicals and pesticides. Other CBD products have been shown to differ from what the label says, either with way more cannabidiol, or way less. In some cases, the THC content was elevated above the federal legal limit for hemp extracts.
At the top of our ranking is Utah-based Kanibi, which is on a mission to create high-quality, science-based CBD products with total transparency. Their consciously crafted CBD is sourced from organic, Kentucky-grown hemp which is farmed with organic farming methods. With great tasting products, free shipping, and a 30-day, no questions asked return policy, you really can’t go wrong with Kanibi.
Fab CBD offers full refunds for all products returned within 30 days of the original purchase. Inexpensive shipping rates are also available; most customers receive their delivery within seven or fewer business days. Customers can contact Fab CBD by phone or email if they have questions or concerns about their delivery. Those who join the brand’s online community qualify for product discounts, as well.
Is CBD Legal? Hemp-derived CBD products (with less than 0.3 percent THC) are legal on the federal level, but are still illegal under some state laws. Marijuana-derived CBD products are illegal on the federal level, but are legal under some state laws. Check your state’s laws and those of anywhere you travel. Keep in mind that nonprescription CBD products are not FDA-approved, and may be inaccurately labeled.

The majority of users prefer full spectrum products because they provide synergistic benefits of the whole plant. These products include an array of the naturally-occurring cannabinoids and terpenes from cannabis. Full spectrum CBD oil has up to 0.3% THC to produce the “entourage effect.” CBD oil products with zero THC are known as either “broad spectrum” or “isolates.” These products are generally preferred by those who want to use CBD but either have an aversion to THC or concerns about drug testing.
Secondly, all products are NOT created equal – they differ significantly in strength, absorption, and elimination by the body and in the manner in which they are formulated. One should be mindful of the differences in doses available for each of these products, starting at a low or moderate dose and increasing as needed in order to find the lowest dose that provides the desired relief. In this way, one can individualize usage to maximize effectiveness while minimizing risk – a proper goal for the use of all medicinals.

CO2 extraction is one of the most common ways CBD is extracted from the hemp or cannabis plants. This method uses expensive equipment that adjusts temperature and pressure to extract the cannabinoids from the plant material, without damaging them. The other common method is to use solvents like ethanol or butane to extract the plant material. These solvents have to be burned off the final product which may damage the cannabinoids or terpenes in the process. There is also a risk that these solvents may not have burned off completely and could end up in your end product.


At the top of our ranking is Portland-based Lazarus Naturals, which has honed a reputation for high-quality, affordable CBD. Their consciously crafted CBD is sourced from organic, Oregon-grown hemp which the company controls from seed to sale. With low prices, a robust assistance program, free shipping, and a 30-day, no questions asked return policy, you really can’t go wrong with Lazarus Naturals.
The majority of users prefer full spectrum products because they provide synergistic benefits of the whole plant. These products include an array of the naturally-occurring cannabinoids and terpenes from cannabis. Full spectrum CBD oil has up to 0.3% THC to produce the “entourage effect.” CBD oil products with zero THC are known as either “broad spectrum” or “isolates.” These products are generally preferred by those who want to use CBD but either have an aversion to THC or concerns about drug testing.
All of NuLeaf’s hemp plants are grown on licensed farms in Colorado using sustainable and 100% organic farming practices. Nuleaf’s CBD oils are made using whole plant extraction. That means the final product is a full-spectrum rather than CBD isolate. Moreover, NuLeaf doesn’t include any additives like preservatives, emulsifiers, or even flavors so the final product remains in its purest form.
Transparency: Fab’s website features third-party lab results for most products. They only have a lab test for one of their tinctures though (which shows results for cannabinoid potency, as well as contaminants like pesticides). Customer service pointed out that the same CBD oil is used for all their products, but since potencies do vary, we appreciate companies that show potency testing for all products.
CBD topicals: Many people take CBD to manage chronic pain. These folks may find  CBD topicals particularly therapeutic, as they can massage the CBD into the skin of the area causing them pain. Dosing can be more imprecise with CBD topicals, and you may need to reapply often to continue feeling the effect. CBD topicals describes a broad category of products including CBD balms, lotions, chopsticks, and creams.
CBD Essence is another brand we’ve had plenty of experience with over the past 18 months or so, and my partner particularly likes his 600 mg Medicinal Grade tincture for quickly easing her anxiety. I haven’t tried them so much for may pain, but I do recall that a 30 mg dose was quite effective the last time I did take it. Also, the main reason they’re this high up on our list is because they’re a fair amount cheaper than Elixinol and PureKana. Their tinctures come in larger 2 oz bottles, but on a CBD-per-mg basis they’re about 20% less expensive than other top-quality brands.
Through its regularly updated and highly informative blog, Koi CBD goes the extra mile to help its customers learn about new developments in the field of CBD use. The company also helps its patrons out by publishing full lab results on each of its products, helping CBD oil users know exactly what to expect. And those purchases may include Koi’s bespoke full-spectrum CBD oil blend, complete with fellow cannabinoids CBDV, CBN and CBG – the inclusion of which, the company claims, “provide[s] the ultimate experience in CBD.” Also available to buy from Koi’s website are a range of 1,000 mg vaping liquids, lavender-scented body lotion, tropical-flavored gummies and, for canine CBD lovers, chewable treats.
Cutting-edge science has shown that the endocannabinoid system is dysregulated in nearly all pathological conditions. Thus, it stands to reason that “modulating endocannabinoid system activity may have therapeutic potential in almost all diseases affecting humans,” as Pal Pacher and George Kunos, scientists with the U.S. National Institutes of Health (NIH), suggested in a 2014 publication.
The growth of CBD Pure within the last several months has been somewhat surprising given their little-known status the first time I tried them last year. They’re not quite as potent and long-lasting as something like Premium Jane or PureKana, but like CBD Essence they’ve mostly made it this high up on the list due to their affordable prices. Believe it or not, in fact, they’re nearly 60% cheaper than PureKana on an oz-to-oz basis. If you’re just trying out CBD for the first time and want to see how it works for you before jumping to one of the more expensive brands, I’d definitely take a look at CBD Pure’s range of affordable tinctures.

This is a confusing one for many people. "A lot of brands don't do a good job of clearly instructing their consumer on the dosing," says Chris Roth, CEO and co-founder of Highline Wellness. When thinking about dosing, also consider whether your CBD is full-spectrum or isolate: Full-spectrum could include other cannabinoids like cannabidivarin or cannabigerol (this is important, since "there's something called the 'entourage effect' when all together, they're more effective than any one of them alone," Roth explains), while isolate is 100% CBD. "Some people might only need 10 milligrams of full-spectrum CBD, but with isolate, even taking 80 or 100 milligrams might not have the same effect," he says.
Buying online is less reliable still because there’s no regulation or standardization. What you see on the label may not be what you are getting. A 2017 study in JAMA found that of the 84 CBD products researchers bought online, 43 percent had more CBD than indicated, while 26 percent had less, and some had unexpected THC.“There’s a 75 percent chance of getting a product where the CBD is mislabeled,” says Marcu, one of the study’s coauthors.

Along with PureKana and CW Hemp, I would say that Green Roads CBD oil probably rounds out the top 3 most popular hemp companies selling online, and that would generally translate to status as the “best CBD oil,” right? They have an incredible web presence, and in fact run a really great blog that you should keep up with if you’re interested in the latest CBD news, trends, etc. They’re also big into offering loads of different product, including pre-dosed pens called “Daily Doses,” CBD terpenes, edibles, and even potent CBD concentrates that you can dab (I don’t have a dab rig myself, but I have friends who say the potency is incredible). Honestly, you’ve just got to check out their website in order to get a better idea of the huge range of products they’ve got — all of which are of the highest quality.  

But because all these products are illegal according to the federal government, cannabis advocates are cautious. “By and large, the federal government is looking the other way,” says Paul Armentano, deputy director of the Washington, DC–based National Organization for the Reform of Marijuana Laws (NORML), but until federal laws are changed, “this administration or a future one could crack down on people who produce, manufacture, or use CBD, and the law would be on its side.”
CBD Essence is another brand we’ve had plenty of experience with over the past 18 months or so, and my partner particularly likes his 600 mg Medicinal Grade tincture for quickly easing her anxiety. I haven’t tried them so much for may pain, but I do recall that a 30 mg dose was quite effective the last time I did take it. Also, the main reason they’re this high up on our list is because they’re a fair amount cheaper than Elixinol and PureKana. Their tinctures come in larger 2 oz bottles, but on a CBD-per-mg basis they’re about 20% less expensive than other top-quality brands.
*[A couple things of note before I begin the reviews. In order to avoid redundancy and limit repeating myself dozens of times over, be advised that (unless otherwise noted), all of the companies listed below employ standard practices that are used by all of the best CBD oil companies, including things like: solventless CO2 extraction, 3rd party laboratory testing, legal THC limits below 0.3%, shipping to all 50 U.S. states, etc..]
The main thing that is inherently clear when scouting out FabCBD (which is a super new brand by the way that only just got started this year), is that they’ve made a pretty serious effort to develop a modern lifestyle brand. If you take a look at their website, everything from the web design to the brand labeling to the text they use screams modern and hip.

This is a confusing one for many people. "A lot of brands don't do a good job of clearly instructing their consumer on the dosing," says Chris Roth, CEO and co-founder of Highline Wellness. When thinking about dosing, also consider whether your CBD is full-spectrum or isolate: Full-spectrum could include other cannabinoids like cannabidivarin or cannabigerol (this is important, since "there's something called the 'entourage effect' when all together, they're more effective than any one of them alone," Roth explains), while isolate is 100% CBD. "Some people might only need 10 milligrams of full-spectrum CBD, but with isolate, even taking 80 or 100 milligrams might not have the same effect," he says.
Koi CBD probably should be higher up on this list given their popularity, but since they’re geared more towards vaping and CBD vape oils, and I have never really used them too much. People who do use them everyday though say that they’ve got the best flavors of any CBD vape oil on the market, and I can say personally that their CBD gummies and spearmint CBD oil work decently as well. I would recommend Koi CBD if you’re big into vaping and have yet to find a CBD vape oil that you like, and/or if you’re looking for a reputable brand that sells high quality oral CBD tinctures as well as edibles and vape products – might as well order everything in one place.

Lisa Hamilton, a jeweler and doula in Brooklyn, NY, knows about the side effects. She recently tried CBD for the shoulder pain that plagued her five years after an accident. Her doctor certified that she was in chronic pain, which under New York State law allowed her to buy from a state dispensary. One Friday, she swallowed two 10-mg capsules, the amount recommended at the dispensary, then took another two on Saturday. “By Sunday, it felt like I’d gotten hit by a truck. Every muscle and joint ached,” Hamilton says. She cut back to one pill a day the following week, but still felt hungover. She stopped after that.
In your internet travels, you may also come across products called “terpsolates.” The manufacturers of these products infuse CBD Isolate with terpenes (but not cannabinoids like THC). These terpenes may enhance the effectiveness of CBD — or maybe they just make it smell good. This may be a good place to point out that not all CBD products are created equal. The industry is still largely unregulated, and the quality and quantity of CBD in a given product will vary wildly. Third-party testing definitely helps to monitor companies’ claims, but it’s still up to you as the consumer to do your homework on the best CBD products.

The human body also produces cannabinoids, known as endocannabinoids, in a bodily system known as the endocannabinoid system (or ECS). The ECS promotes homeostasis by regulating a wide range of functions, including motor skills, mood, appetite, and sleep. As we age, our ECS produces fewer endocannabinoids; they may also decrease due to physical injury or disease. Replenishing depleted endocannabinoids with phytocannabinoids like CBD can help restore balance to the body.


But because all these products are illegal according to the federal government, cannabis advocates are cautious. “By and large, the federal government is looking the other way,” says Paul Armentano, deputy director of the Washington, DC–based National Organization for the Reform of Marijuana Laws (NORML), but until federal laws are changed, “this administration or a future one could crack down on people who produce, manufacture, or use CBD, and the law would be on its side.”
DISCLOSURE: The statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease. All information presented here is not meant as a substitute for or alternative to information from health care practitioners. Please consult your health care professional about potential interactions or other possible complications before using any product.
Customer Service/Shipping: Free 3-7 day shipping for all US orders, with Rush Shipping available. Customer service hours are 10am to 5pm Central Time. SabaiDee offers a 30-day return policy, along with a unique trial program. Under their 100% Happiness Guarantee, you can try out their tinctures for 30 days, and if you don’t like them, return them for a partial refund.
Success stories like Oliver’s are everywhere, but there’s not a lot of data to back up those results. That’s because CBD comes from cannabis and, like nearly all other parts of the plant, is categorized by the Drug Enforcement Agency (DEA) as a Schedule 1 drug—the most restrictive classification. (Others on that list: heroin, Ecstasy, and peyote.) This classification, which cannabis advocates have tried for years to change, keeps cannabis-derived products, including CBD, from being properly studied in the U.S.
In addition to an unflavored option, the drops also come in peppermint and goji berry flavors that are perfect for mixing with beverages. The nutritional information for all three flavors is found on the PlusCBD Oil website. The drops are fairly inexpensive, priced at $0.15 per mg or lower depending on the concentration. The brand offers fast shipping throughout the U.S. and to a wide range of international destinations.
You’ve probably seen PureKana listed on several other “best CBD oils” lists, and it’s for good reason; in our experience (along with maybe a couple of other close competitors), they offer the best overall value in terms of potency, price, customer service, and most importantly, effectiveness. In fact, if I wasn’t continuously trying out new stuff and dedicated to reviewing every single hemp product on the market in an effort to reveal the absolute best CBD oil, I would probably use them exclusively for my lower back pain. Likewise, my partner has said several times that the 600 mg Vanilla tincture is one of his favorites for helping him sleep through the night.
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