The CBDistillery has two main strengths. The first is its variety of options. The CBDistillery offers CBD oil tinctures in a wide range of concentrations from 17mg up to 88 mg of CBD per serving. But what really sets the company apart is that they offer both full-spectrum and THC-free CBD oil options. Most people gravitate towards full-spectrum CBD oil to take advantage of the entourage effect. But with THC-free CBD oil, you can enjoy the benefits and effects of CBD even if you’re subject to mandatory drug testing.
*[A couple things of note before I begin the reviews. In order to avoid redundancy and limit repeating myself dozens of times over, be advised that (unless otherwise noted), all of the companies listed below employ standard practices that are used by all of the best CBD oil companies, including things like: solventless CO2 extraction, 3rd party laboratory testing, legal THC limits below 0.3%, shipping to all 50 U.S. states, etc..]
To make matters more confusing, nine states (including California, Washington, and Colorado) let residents buy cannabis-based products with or without THC. Nearly two dozen other “medical marijuana states” allow the sale of cannabis, including capsules, tinctures, and other items containing CBD or THC, at licensed dispensaries to people whose doctors have certified that they have an approved condition (the list varies by state but includes chronic pain, PTSD, cancer, autism, Crohn’s disease, and multiple sclerosis). Sixteen more states legalized CBD for certain diseases.
Not all CBD is created equally. Some tinctures are created with little regard to overall consumer safety, and may contain harmful chemicals and pesticides. Other CBD products have been shown to differ from what the label says, either with way more cannabidiol, or way less. In some cases, the THC content was elevated above the federal legal limit for hemp extracts.
Nearly every expert Health spoke to agreed that your CBD products should be tested by a third party to confirm the label's accuracy. This is a real concern in the industry—take the 2017 Journal of the American Medical Association study, for example, which tested 84 CBD products and found that 26% contained lower doses than stated on the bottle. Look for a quality assurance stamp or certificate of analysis from a third party (aka not the actual brand) or check the retailer's website if you don't see it on the product's label.
Many expect easy answers and fast results. But as many who have achieved success can attest, there’s no substitute for doing your own research, accepting that there will be some trial and error, and having a good deal of patience to find what works well for you. The good news is that when you buy from one of the companies listed above, you know that you are getting a quality product from a reputable company. Many users have had success with each of these companies for a variety of conditions.
DISCLOSURE: The statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease. All information presented here is not meant as a substitute for or alternative to information from health care practitioners. Please consult your health care professional about potential interactions or other possible complications before using any product.
Endoca’s commitment to social responsibility is such that it even has its own non-profit, The Endoca Foundation. This organization takes in the company’s Endoca Institute of Cannabis, Natural Medicine and Sustainability, which acts as a hub for education and research into medical cannabis; it also spearheads a hardship fund designated for those who wish to investigate the potential benefits of CBD oil products for themselves but lack the funds to do so. By purchasing Endoca products, then, as the producer claims on its website, “customers are not only helping to heal others but also the world.” Moreover, those customers can choose from Endoca’s array of skin care products and drops and even its variety of CBD oil chewing gum – all including oil from hemp plants cultivated using the company’s individual seed bank.
All material provided within this website is for informational and educational purposes only, and is not to be construed as medical advice or instruction. No action should be taken solely on the contents of this website. Consult your physician or a qualified health professional on any matters regarding your health and well-being or on any opinions expressed within this website. The information provided in our newsletters and special reports is believed to be accurate based on the best judgement of the Company and the authors. However, the reader is responsible for consulting with their own health professional on any matters raised within. Neither the company nor the author's of any information provided accept responsibility for the actions or consequential results of any action taken by any reader.
Currently, the only CBD product approved by the Food and Drug Administration is a prescription oil called Epidiolex. It's approved to treat two types of epilepsy. Aside from Epidiolex, state laws on the use of CBD vary. While CBD is being studied as a treatment for a wide range of conditions, including Parkinson's disease, schizophrenia, diabetes, multiple sclerosis and anxiety, research supporting the drug's benefits is still limited.
People taking other medications: When side effects are reported, it’s often by this group. CBD appears to have a similar effect to grapefruit on the liver’s ability to metabolize certain drugs, which can lead to adverse side effects. Generally, if a medication has a grapefruit warning, you should avoid taking CBD. Although, if you are on any medication you should talk to your doctor before starting CBD, to ensure you won’t expect any negative interactions.
Most human studies of CBD have been done on people who have seizures, and the FDA recently approved the first CBD-based drug, Epidiolex, for rare forms of epilepsy. Clinical trials for other conditions are promising, but tiny. In one Brazilian study published in 2011 of people with generalized social anxiety disorder, for example, taking a 600-mg dose of CBD (higher than a typical dose from a tincture) lessened discomfort more than a placebo, but only a dozen people were given the pill.
Our bodies are thought to produce endocannabinoids by the billions every day. “We always thought the ‘runner’s high’ was due to the release of dopamine and endorphins. But now we know the euphoria is also from an endocannabinoid called anandamide,” its name derived from the Sanskrit word for bliss, says Joseph Maroon, MD, clinical professor and vice chairman of neurosurgery at the University of Pittsburgh Medical Center. We produce these natural chemicals all day, but they fade quickly because enzymes pop up to destroy them. That’s where CBD comes in: By blocking these enzymes, CBD allows the beneficial compounds to linger.
Cannabidiol, or CBD for short, is a phyto-cannabinoid found in cannabis plants. However, it does not cause the same psychoactive effects as other naturally occurring cannabinoids (such as tetrahydrocannabinol, or THC). CBD induces feelings of sleepiness and tranquility, making it suitable for insomnia and other sleep disorders; CBD can be used to alleviate symptoms of epilepsy, diabetes, and anxiety disorders, as well. Legality is an issue for some; all 50 states have laws governing the sale, possession, and use of CBD, and they vary significantly (see the table below for a full analysis). 

All this talk about THC lands us nicely in the whole “Full Spectrum vs. Pure Isolate” debate. Once you begin shopping for CBD products, you’ll notice a lot of jargon that gets thrown around without much explanation. Now that we’ve introduced THC into the conversation, we can talk about the difference between, and relative benefits of, Full Spectrum CBD and CBD Isolate (and the lesser-known contender: Broad Spectrum).
Along with PureKana and Premium Jane, MedTerra CBD is one of the few companies that has a commercialization agreement with hemp farms under the Kentucky Pilot Research Program. My partner and I really like this brand because it’s clear that they’re much more focused on health and science rather than creating gimmicky promotions and web advertisements to try and build their “brand.” The CBD industry definitely needs more companies with this mentality. We haven’t tried them a whole lot, but we did receive a couple of samples of their “Medoil Tinctures,” and they worked particularly well for my partner’s anxiety and sleep issues. They also were OK for my back pain, but not quite as potent as some other brands I’ve used.

Even complete CBD novices should be thoroughly clued up on the compound and its effects after visiting the handy education section on Infinite CBD’s website. And for those who want to give CBD oil a try but don’t know where to start, there’s also a welcome chart breaking down the ways in which to consume the phytocannabinoid and the products most suited to each method. So, while Infinite CBD’s range may not be as extensive as those of other businesses of its kind, any such shortfall is more than made up for by the wealth of valuable information available to potential customers. What the company does offer, moreover, is good-value isolates – the strongest of which comes in at a powerful 5,000 mg – and capsules blended with caffeine and melatonin for day and night use, respectively. Meanwhile, people with muscle and joint problems might find relief from Infinite CBD’s “Freezing Point” cooling cream.
You won’t have to worry about potency with Spruce CBD. That’s because the potency of Spruce’s CBD oils are verified by a third-party testing lab. Spruce carries both regular and high potency CBD oil formulations. Spruce’s regular potency CBD oil contains a moderate dose of 25 mg of CBD per serving while their max potency formulation packs a strong dose of 80 mg of CBD per serving.
So let’s get something straight; Mary’s Nutritionals is the sister company of Mary’s Medicinals (actually they’re the same company), which is one of the cannabis industry’s most established names in cannabis CBD oil – that is to say, CBD oil that is extracted from marijuana and only legal in states with medical legalization (and for those with valid MMJ cards). Mary’s Nutritionals is the legal “hemp-based” version of Mary’s Medicinals; they extract their products industrial hemp like all other brands on the list, and thus are able to ship to all 50 U.S. states. Truth be told I don’t have a ton of experience with them because they’re so expensive, but believe me – their “Remedy” line of CBD oils are easily the best products on the market. That is, if you’re ready to splurge the cash on them. Also, they’re the only company we’re aware of that sells a legal CBD transdermal patch that you use like a nicotine patch. I’ve never actually tried it before, but I heard it works incredibly well.
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