Lisa Hamilton, a jeweler and doula in Brooklyn, NY, knows about the side effects. She recently tried CBD for the shoulder pain that plagued her five years after an accident. Her doctor certified that she was in chronic pain, which under New York State law allowed her to buy from a state dispensary. One Friday, she swallowed two 10-mg capsules, the amount recommended at the dispensary, then took another two on Saturday. “By Sunday, it felt like I’d gotten hit by a truck. Every muscle and joint ached,” Hamilton says. She cut back to one pill a day the following week, but still felt hungover. She stopped after that.
Our bodies are thought to produce endocannabinoids by the billions every day. “We always thought the ‘runner’s high’ was due to the release of dopamine and endorphins. But now we know the euphoria is also from an endocannabinoid called anandamide,” its name derived from the Sanskrit word for bliss, says Joseph Maroon, MD, clinical professor and vice chairman of neurosurgery at the University of Pittsburgh Medical Center. We produce these natural chemicals all day, but they fade quickly because enzymes pop up to destroy them. That’s where CBD comes in: By blocking these enzymes, CBD allows the beneficial compounds to linger.
Cannabidiol (CBD) is a naturally occurring compound found in the resinous flower of cannabis, a plant with a rich history as a medicine going back thousands of years. Today the therapeutic properties of CBD are being tested and confirmed by scientists and doctors around the world. A safe, non-addictive substance, CBD is one of more than a hundred “phytocannabinoids,” which are unique to cannabis and endow the plant with its robust therapeutic profile. 

The human body also produces cannabinoids, known as endocannabinoids, in a bodily system known as the endocannabinoid system (or ECS). The ECS promotes homeostasis by regulating a wide range of functions, including motor skills, mood, appetite, and sleep. As we age, our ECS produces fewer endocannabinoids; they may also decrease due to physical injury or disease. Replenishing depleted endocannabinoids with phytocannabinoids like CBD can help restore balance to the body.
As a result, Sabaidee CBD oil is some of the best out there. Made without any fillers, this company’s CBD oil contains just full-spectrum hemp extract, medium-chain triglyceride (MCT) oil from coconut, and natural peppermint oil for flavor. They offer three potencies (8.33 mg, 33.5 mg, and 88.3 mg of CBD per serving) to suit a wide range of customer needs.
In response to the FDA’s historic decision, the Drug Enforcement Administration (DEA) announced in September 2018 that it had removed Epidiolex from Schedule I classification, a category reserved for dangerous drugs with no medical value. Henceforth, Epidiolex would be considered a Schedule V drug, the least dangerous designation under the Controlled Substances Act.
CBD has proven neuroprotective effects and its anti-cancer properties are being investigated at several academic research centers in the United States and elsewhere. A 2010 brain cancer study by California scientists found that CBD “enhances the inhibitory effects of THC on human glioblastoma cell proliferation and survival.” This means that CBD makes THC even more potent as an anticancer substance. Also in 2010, German researchers reported that CBD stimulates neurogenesis, the growth of new brain cells, in adult mammals.
Transparency: cbdMD seems to be going through a transition with their third-party testing practices. Until recently, they only released a lab report for the CBD concentrate they use for all their products, but would not show potency testing for individual products. That seems to be changing. Currently, the only lab report on the website is for their concentrate (and it’s over a year old). But if you contact customer service, they’ll send you a lab report for any product. 
Hemp-derived CBD products were made federally legal in December 2018 with the signing of the 2018 Farm Bill. However, several states still have laws in place that restrict the sale and possession of these products. Most companies selling CBD oil are shipping to all 50 states. You should consult your local laws or an attorney in your area if you have concerns about legalities.
The growth of CBD Pure within the last several months has been somewhat surprising given their little-known status the first time I tried them last year. They’re not quite as potent and long-lasting as something like Premium Jane or PureKana, but like CBD Essence they’ve mostly made it this high up on the list due to their affordable prices. Believe it or not, in fact, they’re nearly 60% cheaper than PureKana on an oz-to-oz basis. If you’re just trying out CBD for the first time and want to see how it works for you before jumping to one of the more expensive brands, I’d definitely take a look at CBD Pure’s range of affordable tinctures.

Los Angeles-based PureKana stresses that it extracts the CBD oil for its products from hemp plants that have been cultivated without the use of herbicides, pesticides or other agro-industrial chemicals that may impact upon crops. What’s more, the company states, no solvents go into the extraction process other than carbon dioxide. And to further put potential customers’ minds at rest, PureKana presents the results of third-party testing of its CBD oil tincture on its website – a welcome nod to transparency. That tincture can be found in the company’s own blend of CBD oil drops – the three varieties of which have elicited highly complimentary reviews from users – as well as its capsules and cooling topical ointment. Meanwhile, for anyone with a sweet tooth, PureKana’s CBD isolate-containing gummy bears may just do the trick.
Pregnant or breastfeeding women: Because researchers don’t want to put the mother or fetus in danger, clinical studies typically don’t include pregnant and breastfeeding women. As a result, physicians can’t definitively say whether or not CBD is safe for expecting and new mothers. Not enough research has been done. However, one study did find that CBD increased the permeability of the placental barrier, which could put the fetus at risk.
There are many scammers and multi-level marketing salespeople that use Facebook and other social media outlets to push a particular product. Many of them will tell you whatever you want to hear to get you to buy from them. Be wary of their claims and testimonials. It’s particularly important to buy CBD oil from a brand that makes third party lab reports readily available. This third party certification is the only way for you to truly know what is in the product.
CBD oil alleviates physical pain and anxiety – both of which can have a negative impact on sleep. Additionally, CBD oil can actually prolong sleep for some, leading to more rest from night to night. Most medical experts agree that marijuana is not particularly beneficial for individuals with medical conditions and/or mental health disorders, as the THC can increase their symptoms; this makes CBD oil a good alternative option for people with the following sleep disorders and medical conditions.
Although CBD oils aren’t regulated by the FDA, purchasing products stateside from one of the nine states where recreational and medical cannabis use is legal will likely result in a higher-quality product than buying one made with hemp-derived CBD oil imported from abroad, says Martin Lee, director of Project CBD, a nonprofit that promotes medical research into CBD.

Transparency: Moon Mother sends each batch of product to a third-party lab to be tested for potency as well as other contaminants. You can find all of these lab reports on the company’s website. They also added more information about their company processes to the website, so it’s easier to find important information about extraction and manufacturing.

Hemptation Infused Goods scores points for innovation thanks to its unusual CBD oil-infused honey, which is harvested from hives in Vermont and, according to the company, has a “slightly spicy bite.” That said, customers who prefer not to get their CBD hit on toast may instead opt for one of Hemptation’s similarly novel bath bombs, designed to either invigorate or help unwind when the user settles in for a soak. More traditional types might be relieved to hear, however, that the company also offers sublingual CBD oils in dropper bottles, 99-percent pure slabs of CBD isolate and wax – the latter made from a whole extract of the hemp plant. Furthermore, Hemptation arguably takes customer service to the next level by offering in-person consultations about CBD, available to those living in Massachusetts or Vermont for a $60 fee. Anyone further afield, meanwhile, can take advantage of a similar but more inexpensive service by either telephone or live chat online.
As a result, Sabaidee CBD oil is some of the best out there. Made without any fillers, this company’s CBD oil contains just full-spectrum hemp extract, medium-chain triglyceride (MCT) oil from coconut, and natural peppermint oil for flavor. They offer three potencies (8.33 mg, 33.5 mg, and 88.3 mg of CBD per serving) to suit a wide range of customer needs.
CBD oil alleviates physical pain and anxiety – both of which can have a negative impact on sleep. Additionally, CBD oil can actually prolong sleep for some, leading to more rest from night to night. Most medical experts agree that marijuana is not particularly beneficial for individuals with medical conditions and/or mental health disorders, as the THC can increase their symptoms; this makes CBD oil a good alternative option for people with the following sleep disorders and medical conditions.
Hemp-derived CBD products were made federally legal in December 2018 with the signing of the 2018 Farm Bill. However, several states still have laws in place that restrict the sale and possession of these products. Most companies selling CBD oil are shipping to all 50 states. You should consult your local laws or an attorney in your area if you have concerns about legalities.
And now, onto the thorny issue of legality. The simple answer to the question is yes — if it is extracted from hemp. The 2014 Farm Bill established guidelines for growing hemp in the U.S. legally. This so-called “industrial hemp” refers to both hemp and hemp products which come from cannabis plants with less than 0.3 percent THC and are grown by a state-licensed farmer.
As noted in the previous section, CBD oil prices vary significantly by brand. The best practice for most is to determine a per-milligram budget for CBD oil, as well as a maximum price for the entire bottle. For example, you might decide that 10 cents per milligram or less is a reasonable budget; and that $45 (for a 450-mg concentration, based on the budget) is a maximum bottle price. Also, if ordering online, be sure to include potential shipping costs.
Employee-owned Lazarus Naturals touts its commitment to ethical business practices, including pricing that aims to enable anyone to sample its range. Indeed, for veterans and those with long-term disabilities, there’s even a commendable 40-percent discount on the company’s wares. Customers wanting more bang for their buck could, then, try Lazarus Naturals’ 3,000 mg flavorless CBD tincture, a 60 ml bottle of which costs $125, though an even more potent 6,000 mg tincture is also available. Plus, the supplier’s handy and inexpensive taster packs may be a boon for more indecisive or novice CBD oil users. These packs come in regular and high-potency varieties, both of which contain samples of the company’s tinctures, capsules and CBD-infused coconut oil.
Non-THC CBD oils can be highly effective, and are suitable for employees who face random or routine drug tests. Our top pick for this category is the Medterra CBD Oil Tincture, which contains 99.6% CBD and MCT oil (also known as coconut oil extract) without any traces of THC. The oil is derived from hemp plants that are free of GMOs and pesticides, as well. All third-party testing results for the oil are accessible through Medterra’s official product page.
When it comes to bang for the buck, Lazarus Naturals is the industry leader. They’ve built a loyal customer base because of their low prices, high-quality products, and compassionate assistance program for those in need. In fact, they’ve been voted the Brand of the Year by members of the CBD Oil Users Group on Facebook for the last 3 years. We particularly like their dedication to posting third-party lab reports on their website by batch. Their 30-day money-back guarantee speaks to the confidence in the quality of their products which clearly makes them one of the best CBD oil brands on the market.

If you haven’t been bombarded with CBD marketing or raves about it from friends, get ready. This extract—which comes from either marijuana or its industrial cousin, hemp—is popping up everywhere. There are CBD capsules, tinctures, and liquids for vaping plus CBD-infused lotions, beauty products, snacks, coffee, and even vaginal suppositories. Already some 1,000 brands of CBD products are available in stores—and online in states that don’t have lenient cannabis laws. This is a tiny fraction of what’s to come: The CBD market is poised to exceed $22 billion by 2022, per the Chicago-based research firm Brightfield Group.
Water soluble CBD oil products are formulated using a special process to break down the CBD molecules into smaller particles. In theory, “water compatability” would produce higher absorption rates and faster-acting effects. Although it’s a popular buzzword in the CBD industry, we have yet to see any independent research studies that prove they are better than traditional oil-based tinctures.
But because all these products are illegal according to the federal government, cannabis advocates are cautious. “By and large, the federal government is looking the other way,” says Paul Armentano, deputy director of the Washington, DC–based National Organization for the Reform of Marijuana Laws (NORML), but until federal laws are changed, “this administration or a future one could crack down on people who produce, manufacture, or use CBD, and the law would be on its side.”
You know how you check your raw chicken or bagged lettuce every time there's a recall to make sure the one you bought isn't going to make you sick? You should be able to do that with CBD products too. "This is a huge indicator as to whether they are following good manufacturing practices," says Beatty. "There should be a way to identify this product in case it was improperly made so the company can carry out a recall."
CBD has proven neuroprotective effects and its anti-cancer properties are being investigated at several academic research centers in the United States and elsewhere. A 2010 brain cancer study by California scientists found that CBD “enhances the inhibitory effects of THC on human glioblastoma cell proliferation and survival.” This means that CBD makes THC even more potent as an anticancer substance. Also in 2010, German researchers reported that CBD stimulates neurogenesis, the growth of new brain cells, in adult mammals.
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