CW Hemp’s Charlotte’s Web strain of hemp came to national attention in 2013 after it was featured on a CNN segment telling the story of Charlotte Figi. Figi has Dravet syndrome, a form of epilepsy; CNN has reported, however, that after the girl began to take CW Hemp’s CBD oil, her seizures radically reduced in number. A touching update to Figi’s tale can be found on CW Hemp’s website, where those looking to see how the company’s CBD oil products might benefit them are able to purchase capsules, cream and balm. Frequent customers, meanwhile, can take advantage of the brand’s hemp oil bulk package, which offers five regular-sized bottles of CW Hemp’s bespoke blends for the price of four – making it a more cost-effective way for some to get their daily dose of CBD.
In addition to an unflavored option, the drops also come in peppermint and goji berry flavors that are perfect for mixing with beverages. The nutritional information for all three flavors is found on the PlusCBD Oil website. The drops are fairly inexpensive, priced at $0.15 per mg or lower depending on the concentration. The brand offers fast shipping throughout the U.S. and to a wide range of international destinations.
CBD is a chemical found in marijuana. CBD doesn't contain tetrahydrocannabinol (THC), the psychoactive ingredient found in marijuana that produces a high. The usual CBD formulation is oil, but CBD is also sold as an extract, a vaporized liquid and an oil-based capsule. Food, drinks and beauty products are among the many CBD-infused products available online.
CO2 extraction is one of the most common ways CBD is extracted from the hemp or cannabis plants. This method uses expensive equipment that adjusts temperature and pressure to extract the cannabinoids from the plant material, without damaging them. The other common method is to use solvents like ethanol or butane to extract the plant material. These solvents have to be burned off the final product which may damage the cannabinoids or terpenes in the process. There is also a risk that these solvents may not have burned off completely and could end up in your end product.

That same 2018 Farm Bill means you can now travel between states with legit CBD products. "Flying with CBD should pose no issues now," Parrish says. However, if you're traveling with a tincture, be mindful of TSA limits on how much liquid you can carry on an airplane, she adds. (You can also mail CBD products, just like "companies that comply with the Bill can ship their hemp-derived CBD products anywhere in the U.S.," Parrish notes.)
This means high doses of CBD could significantly decrease the metabolization of cocaine. In fact, a study done on mice found exactly that 11. But what they also found was that CBD only significantly decreased the metabolization of CYP substrates like cocaine, when taken in extremely high doses off 30mg/kg. Such a high CBD dose far surpasses the currently maximum recommended dose of 1500mg/day.

Lisa Hamilton, a jeweler and doula in Brooklyn, NY, knows about the side effects. She recently tried CBD for the shoulder pain that plagued her five years after an accident. Her doctor certified that she was in chronic pain, which under New York State law allowed her to buy from a state dispensary. One Friday, she swallowed two 10-mg capsules, the amount recommended at the dispensary, then took another two on Saturday. “By Sunday, it felt like I’d gotten hit by a truck. Every muscle and joint ached,” Hamilton says. She cut back to one pill a day the following week, but still felt hungover. She stopped after that.
This is a confusing one for many people. "A lot of brands don't do a good job of clearly instructing their consumer on the dosing," says Chris Roth, CEO and co-founder of Highline Wellness. When thinking about dosing, also consider whether your CBD is full-spectrum or isolate: Full-spectrum could include other cannabinoids like cannabidivarin or cannabigerol (this is important, since "there's something called the 'entourage effect' when all together, they're more effective than any one of them alone," Roth explains), while isolate is 100% CBD. "Some people might only need 10 milligrams of full-spectrum CBD, but with isolate, even taking 80 or 100 milligrams might not have the same effect," he says.
Research on CBD and anxiety has generally looked at cannabis as a whole product including THC, not as CBD as a standalone compound. Some studies suggest that it can help with anxiety: like this 2011 study that suggests CBDcan reduce social anxiety or this 2015 review that says CBD could be promising for many forms of anxiety. It’s also important to consider whether the CBD comes from the cannabis plant and therefore may include THC, a cannabinoid that for some, induces anxiety. Read our comprehensive article on CBD and anxiety, here.
“Buying from a reputable manufacturer is crucial, because it matters how the plant is cultivated and processed,” Dr. Maroon says. One clue that a company is cutting corners: too low a cost. Good CBD is pricey—a bottle of high-quality capsules is sold in Cohen’s office for $140. But for many, it’s worth the money. Roth spent $60 on her tiny bottle. But when her energy returned the day she started taking CBD, she decided that was a small price to pay.
Although CBD oils aren’t regulated by the FDA, purchasing products stateside from one of the nine states where recreational and medical cannabis use is legal will likely result in a higher-quality product than buying one made with hemp-derived CBD oil imported from abroad, says Martin Lee, director of Project CBD, a nonprofit that promotes medical research into CBD.
Pioneers of the CBD industry, 4 Corners Cannabis helped pave the way for companies that want to provide quality products and utilize best practices. They grow their own strain of hemp and make small batches of true full-spectrum CBD products. Their prices place them lower down on our ranking, but their highly satisfied customers are more than willing to pay for the 4 Corners quality.  

I would sincerely appreciate your ideas on this and any suggestions you may have. As I said, several of our family (at least six) have pretty severe chronic pain. The youngest is 45 and the oldest is 75. And I have several friends who suffer a lot, so I’m trying to find out all I can and be of some help. I look forward to hearing what you think, and I will definitely be trying those on your list.


Medterra prides itself on offering what it terms “true seed-to-sale purchases,” with the hemp crop used for its CBD oil cultivated and extracted to the exacting standards demanded by the Kentucky Department of Agriculture. Potential buyers may be encouraged, too, to know that “quality, consistency and safety are… top priorities” at Medterra, and to that end all of the raw materials the company uses are independently lab tested. Plus, those who decide to take the plunge and order from the provider’s site can reap the benefits of its rewards program, with points given for Facebook shares, reviews and purchases. Among the products on offer at Medterra are CBD oil tinctures, capsules and pain-alleviating cream, all of which fall under a money-back pledge if not deemed to be to customers’ satisfaction.
For those with little understanding of where CBD comes from, how it can affect the body or even what “CBD” stands for, CBDfx has it all covered through the convenient “Knowledge Hub” section on its website. Meanwhile, anyone searching for further answers may just find what they’re looking for on the company’s blog, which investigates, among other subjects, CBD oil’s impact on the ageing process and whether or not the cannabidiol can assist with anxiety. In all, then, CBDfx helps fully equip potential customers with the information they need before they make a purchase. And if they do decide to buy from this provider, they have plenty of choice, too, as its range of products takes in not only CBD oil tinctures, capsules and gummy bears but also a lemon-flavored “Chill Shot” drink – which, the company claims, is “one of the tastiest and most satisfying ways to dose yourself with CBD.”
That leaves those touting CBD’s effectiveness pointing primarily to research in mice and petri dishes. There, CBD (sometimes combined with small amounts of THC) has shown promise for helping pain, neurological conditions like anxiety and PTSD, and the immune system—and therefore potentially arthritis, diabetes, multiple sclerosis, cancer, and more.
According to the 4 Corners Cannabis website, co-owners Justin and Brian Jasiewicz have 30 years of cannabis growing experience between them. That expertise gives them the know-how, the company claims, to make sure that the entire production process of 4 Corners’ CBD oil is run correctly – all the way from field to store. And while that may result in products that are a little more expensive than equivalents on the market, there could be room for that to change if enough people lobby for lower prices; 4 Corners, for one, emphasizes that it “[listens] to the demands from [their] customers to better serve them in the future.” Meanwhile, the company makes picking the right product that little bit easier through its innovative labeling. This makes it plain at a glance for potential purchasers to see which of the 4 Corners range are designed to improve mental well-being and which, by contrast, are targeted at those with active lifestyles.
Historically, hemp could legally be grown and cultivated for academic research purposes only. However, the legality of hemp growth has changed in the past year. In April 2018, Sen. Mitch McConnell of Kentucky introduced the Hemp Farming Act of 2018, a piece of legislation that proposed legalizing all hemp products at the federal level. The act was incorporated in the 2018 United States Farm Bill, which passed in both the House and Senate in December 2018. Per the farm bill, industrial hemp will be descheduled as a federally controlled substance.
So let’s get something straight; Mary’s Nutritionals is the sister company of Mary’s Medicinals (actually they’re the same company), which is one of the cannabis industry’s most established names in cannabis CBD oil – that is to say, CBD oil that is extracted from marijuana and only legal in states with medical legalization (and for those with valid MMJ cards). Mary’s Nutritionals is the legal “hemp-based” version of Mary’s Medicinals; they extract their products industrial hemp like all other brands on the list, and thus are able to ship to all 50 U.S. states. Truth be told I don’t have a ton of experience with them because they’re so expensive, but believe me – their “Remedy” line of CBD oils are easily the best products on the market. That is, if you’re ready to splurge the cash on them. Also, they’re the only company we’re aware of that sells a legal CBD transdermal patch that you use like a nicotine patch. I’ve never actually tried it before, but I heard it works incredibly well.
Quality CBD oil comes from a quality source. CBD oil can be extracted from the hemp plant in a variety of ways. The safest, and most efficient methods, use carbon dioxide or ethanol as a solvent to separate the CBD from the hemp plant. All of the tinctures below are extracted from pesticide-free hemp grown on local farms in the United States, all of which are registered with their state’s industrial hemp pilot program, or organic-certified farms in Europe.
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