People taking other medications: When side effects are reported, it’s often by this group. CBD appears to have a similar effect to grapefruit on the liver’s ability to metabolize certain drugs, which can lead to adverse side effects. Generally, if a medication has a grapefruit warning, you should avoid taking CBD. Although, if you are on any medication you should talk to your doctor before starting CBD, to ensure you won’t expect any negative interactions.
What exactly is cannabidiol (CBD) and more importantly, what does it do? Those questions and more are at the heart of this comprehensive guide to one of the most fascinating and important compounds of the cannabis plant. Cannabis plants are chemical powerhouses that produce more than 400 different compounds. Not all of those compounds are unique to marijuana, of course, and appear in many other species of plants. That’s why marijuana can smell like pine trees or taste like fresh lemons. But of those 400 compounds, more than 60 of them are totally specific to the plant genus Cannabis. Scientists call these special compounds “cannabinoids.” However, not all cannabinoids are created equal. One of them, cannabidiol, or CBD, holds the key to the wide variety of medicinal and therapeutic effects marijuana offers. 

But because all these products are illegal according to the federal government, cannabis advocates are cautious. “By and large, the federal government is looking the other way,” says Paul Armentano, deputy director of the Washington, DC–based National Organization for the Reform of Marijuana Laws (NORML), but until federal laws are changed, “this administration or a future one could crack down on people who produce, manufacture, or use CBD, and the law would be on its side.”
Another point worth clarifying is the difference between hemp seed oil (or hemp oil) and CBD oil. There’s confusion on this point for the very good reason that both CBD oil and hemp seed oil are extracted from the industrial hemp plant. But there’s a big difference between the 2. Hemp seed oil has been pressed from hemp seed, and it’s great for a lot of things — it’s good for you, tastes great, and can be used in soap, paint — even as biodiesel fuel.

At the top of our ranking is Utah-based Kanibi, which is on a mission to create high-quality, science-based CBD products with total transparency. Their consciously crafted CBD is sourced from organic, Kentucky-grown hemp which is farmed with organic farming methods. With great tasting products, free shipping, and a 30-day, no questions asked return policy, you really can’t go wrong with Kanibi.
Charlotte’s Web is currently one of the top CBD hemp brands in the U.S and is constantly featured on top authority websites such as The Wall Street Journal, Time and The Huffington Post. What started off as a hemp strain packed with CBD to help a girl named Charlotte Figi, soon turned into an empire. Today, Charlotte’s Web, formerly known as CWhemp offers a wide range of high-quality products including oils, capsules and even CBD gummies. Want to learn more check out our Charlotte’s Web CBD oil Review.
Non-THC CBD oils can be highly effective, and are suitable for employees who face random or routine drug tests. Our top pick for this category is the Medterra CBD Oil Tincture, which contains 99.6% CBD and MCT oil (also known as coconut oil extract) without any traces of THC. The oil is derived from hemp plants that are free of GMOs and pesticides, as well. All third-party testing results for the oil are accessible through Medterra’s official product page.
Populum has enough confidence in what it sells to offer a 30-day trial of purchases, with the option to send products back within that period if they don’t live up to expectations. That offer speaks to the company’s customer-friendly ethos – and its willingness to answer any questions that people throw at it via email, phone or live chat does so, too. One customer is quoted on Populum’s website as saying that the company’s risk-free guarantee is “also a testament to [its] commitment to making a high-quality product.” Those wanting to see what the fuss is about can sample Populum’s hemp oil tincture – which comes in 250 mg, 500 mg and 1,000 mg concentrations – and cooling gel, safe in the knowledge that they are able to get their money back if need be.
Quality matters with CBD oil products and so does customer service. There are literally thousands of CBD companies selling products today. Some are real companies with a solid reputation among users and some are fly-by-night operations with no accountability. Of course, all of them will tell you that they have the best products out there. Never pick a brand based on one person’s opinion on social media. Especially if you feel like you are getting a sales pitch. 
Aside from maybe only PureKana, CW Hemp is probably the most popular CBD brand in the U.S. – at least in terms of the amount of product that they sell. And indeed they make some great, highly effective tinctures, but the only reason I don’t have them ranked higher is simply because I think they’re a bit overrated – and overpriced. If you’re into name brand reputation and will feel more comfortable buying from an established company like CW, by all means don’t be afraid to spend the money and try them out – they certainly don’t lack for quality. I just think there are other brands out there that offer better overall value for the amount of money that you’re spending.  
Kat’s Naturals not only takes the quality of its products seriously, but it also ensures that their contents are produced in a way that’s as environmentally friendly as possible. The essential oils in its best-selling Heal CBD Hemp Oil, for example, are harvested in a sustainable manner, while the hemp that goes into its range more generally is completely organically grown. And in a customer-friendly move, Kat’s Naturals provides CBD oil blends specifically tailored to users’ needs, whether they want to boost metabolism, get a good night’s rest or simply feel freer from muscle pain. Perhaps the most innovative Kat’s Naturals product, though, is its CBD-containing capsaicin cream. This topical owes its heat in part to a component commonly found within chili peppers, and the company’s website claims that it also helps give respite to neuropathy sufferers and those with Raynaud syndrome.
Nearly every expert Health spoke to agreed that your CBD products should be tested by a third party to confirm the label's accuracy. This is a real concern in the industry—take the 2017 Journal of the American Medical Association study, for example, which tested 84 CBD products and found that 26% contained lower doses than stated on the bottle. Look for a quality assurance stamp or certificate of analysis from a third party (aka not the actual brand) or check the retailer's website if you don't see it on the product's label.

When it comes to bang for the buck, Lazarus Naturals is the industry leader. They’ve built a loyal customer base because of their low prices, high-quality products, and compassionate assistance program for those in need. In fact, they’ve been voted the Brand of the Year by members of the CBD Oil Users Group on Facebook for the last 3 years. We particularly like their dedication to posting third-party lab reports on their website by batch. Their 30-day money-back guarantee speaks to the confidence in the quality of their products which clearly makes them one of the best CBD oil brands on the market.
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